Endocrine Abstracts

Background: Obesity, resulting from complex interactions between genetic and non-genetic factors, is one the most pressing health challenges in our society. Current treatments for losing weight based mainly on diet and exercise are mostly unsuccessful in the long term. Therefore, as an alternative to the current strategy of one-size-fits-all, a more individualized approach is proposed in which genotype data are used to personalize treatment and to optimize the results.<p c...

Current knowledge supports the notion that the onset and progression of endocrine and age-related diseases depend on an individual’s metabolic flexibility. With respect to cardiometabolic diseases, especially in older persons, several factors act in concert and converge to challenge metabolic flexibility. These include an inadequate diet, insufficient physical activity, chronodisruption, decreased metabolic reserve, altered gut microbiome, and reduced immune system capaci...